Prof. Dr. Jochen Staiger
Prof. Dr. Bernhard Reuss
Gabriele Schmidt
Dr. rer. nat. Julien Guy
Dr. rer. nat. Martin Möck
Dr. med. Rebeka Andrea Palicz
Dr. rer. nat. Joachim Rosenbusch
Dr. rer. nat. Mirko Witte
Merve Özgür Erat
Aybeniz Ece Cetin
Weilin Chen
Xiaoyi Mao
Anouk Meeuwissen
Felix Preuss
Jenifer Rachel
Pauline Antonie Ulmke
Harun Akkoyun
Simon Badura
Thore Behrendt
Felicita Fischer
Janis Hülsemann
Alina Rüppel
Lisa Thiecke
Sabrina Hübner
Christin Korb
Ima Mansori
Nicolas Zdun
Sandra Heinzl
Patricia Sprysch
Pavel Truschow
Dr. rer. nat. Csaba Dávid
Dr. rer. nat. Alvar Prönneke
PD Dr. Michael Rickmann
Dr. Marcel Ruiz Mejias
Dr. rer. nat. Dirk Schubert
Dr. Godwin Sokpor
Dr. rer. nat. Nidhi Subhashini
Dr. rer. nat. Tran Tuoc
Dr. med. Robin Wagener
Dr. rer. nat. Yuanbin Xie
Xiaojuan Zhou
Eman Abbas
Michael Feyerabend
Georg Hafner
Kamila Kiszka
Nieves Mingo Moreno
Ramanathan Narayanan
Huong Nguyen
Florian Walker
Khatuna Aslanishvili
Christina Bachmann
Jürgen Delchmann
Esther Alexandra Dockhorn
Tatjana Fischer
Anna Garcia Galera
Kristina Glöckner
Dilbrin Khelo
Stephen Olt
Bettina Pater
Alexandra Sachkova
Bianca Scheuer
Joris Brehmer
Dennis Dalügge
Julia Dziubek
Ricardo Castro Hernandez
Fernando Gonzalez Ibanez
Anette Mertens
Megha Patwa
Adrián Villalobos
Simon Weiler
Maxim Wintergoller
Anna Dudek
Heike Faust
Ansgar Jahn
Linh Pham

Abbas
Last Name: | Abbas | Position: | PhD Student |
First Name: | Eman | Ort: | |
Akademischer Titel: | Tel.: |
Lebenslauf
Publikationen
2018
Transcriptional and epigenetic control of mammalian olfactory epithelium development.
Sokpor G*, Abbas E*, Rosenbusch J, Staiger JF, Tuoc T..
Molecular Neurobiology (https://doi.org/10.1007/s12035-018-0987-y), 2018.
abstract link
The postnatal mammalian olfactory epithelium (OE) represents a major aspect of the peripheral olfactory system. It is a pseudostratified tissue that originates from the olfactory placode and is composed of diverse cells, some of which are specialized receptor neurons capable of transducing odorant stimuli to afford the perception of smell (olfaction). The OE is known to offer a tractable miniature model for studying the systematic generation of neurons and glia that typify neural tissue development. During OE development, stem/progenitor cells that will become olfactory sensory neurons and/or non-neuronal cell types, display fine spatiotemporal expression of neuronal and non-neuronal genes that ensures their proper proliferation, differentiation, survival, and regeneration. Many factors, including transcription and epigenetic factors have been identified as key regulators of the expression of such requisite genes to permit normal OE morphogenesis. Typically, specific interactive regulatory networks established between transcription and epigenetic factors/cofactors orchestrate histogenesis in the embryonic and adult OE. Hence, investigation of these regulatory networks critical for OE development promises to disclose strategies that may be employed in manipulating the stepwise transition of olfactory precursor cells to become fully differentiated and functional neuronal and non-neuronal cell types. Such strategies potentially offer formidable means of replacing injured or degenerated neural cells as therapeutics for nervous system perturbations. This review recapitulates the developmental cellular diversity of the olfactory neuroepithelium and discusses findings on how the precise and cooperative molecular control by transcriptional and epigenetic machinery is indispensable for OE ontogeny.