Prof. Dr. Jochen Staiger
Prof. Dr. Bernhard Reuss
Gabriele Schmidt
Dr. rer. nat. Julien Guy
Dr. rer. nat. Martin Möck
Dr. med. Rebeka Andrea Palicz
Dr. rer. nat. Joachim Rosenbusch
Dr. rer. nat. Mirko Witte
Merve Özgür Erat
Aybeniz Ece Cetin
Weilin Chen
Xiaoyi Mao
Anouk Meeuwissen
Felix Preuss
Jenifer Rachel
Pauline Antonie Ulmke
Harun Akkoyun
Simon Badura
Thore Behrendt
Felicita Fischer
Janis Hülsemann
Alina Rüppel
Lisa Thiecke
Sabrina Hübner
Christin Korb
Ima Mansori
Nicolas Zdun
Sandra Heinzl
Patricia Sprysch
Pavel Truschow
Dr. rer. nat. Csaba Dávid
Dr. rer. nat. Alvar Prönneke
PD Dr. Michael Rickmann
Dr. Marcel Ruiz Mejias
Dr. rer. nat. Dirk Schubert
Dr. Godwin Sokpor
Dr. rer. nat. Nidhi Subhashini
Dr. rer. nat. Tran Tuoc
Dr. med. Robin Wagener
Dr. rer. nat. Yuanbin Xie
Xiaojuan Zhou
Eman Abbas
Michael Feyerabend
Georg Hafner
Kamila Kiszka
Nieves Mingo Moreno
Ramanathan Narayanan
Huong Nguyen
Florian Walker
Khatuna Aslanishvili
Christina Bachmann
Jürgen Delchmann
Esther Alexandra Dockhorn
Tatjana Fischer
Anna Garcia Galera
Kristina Glöckner
Dilbrin Khelo
Stephen Olt
Bettina Pater
Alexandra Sachkova
Bianca Scheuer
Joris Brehmer
Dennis Dalügge
Julia Dziubek
Ricardo Castro Hernandez
Fernando Gonzalez Ibanez
Anette Mertens
Megha Patwa
Adrián Villalobos
Simon Weiler
Maxim Wintergoller
Anna Dudek
Heike Faust
Ansgar Jahn
Linh Pham

Patwa
Last Name: | Patwa | Position: | Master/Bachelor Student |
First Name: | Megha | Ort: | Göttingen |
Akademischer Titel: | Tel.: |
Lebenslauf
Publikationen
2016
mSWI/SNF (BAF) complexes are indispensable for the neurogenesis and development of embryonic olfactory epithelium.
Bachmann C*, Nguyen H*, Rosenbusch J*, Pham L, Rabe T, Patwa M, Sokpor G, Seong RH, Ashery-Padan R, Mansouri A, Stoykova A, Staiger JF, Tuoc T..
Plos Genetics, 2016.
12(9), *equally contributed authors
abstract link
Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been reported to play essential roles in the neurogenesis of the central nervous system. However, whether BAF complexes are required for neuron generation in the olfactory system is unknown. Here, we identified onscBAF and ornBAF complexes, which are specifically present in olfactory neural stem cells (oNSCs) and olfactory receptor neurons (ORNs), respectively. We demonstrated that BAF155 subunit is highly expressed in both oNSCs and ORNs, whereas high expression of BAF170 subunit is observed only in ORNs. We report that conditional deletion of BAF155, a core subunit in both onscBAF and ornBAF complexes, causes impaired proliferation of oNSCs as well as defective maturation and axonogenesis of ORNs in the developing olfactory epithelium (OE), while the high expression of BAF170 is important for maturation of ORNs. Interestingly, in the absence of BAF complexes in BAF155/BAF170 double-conditional knockout mice (dcKO), OE is not specified. Mechanistically, BAF complex is required for normal activation of Pax6-dependent transcriptional activity in stem cells/progenitors of the OE. Our findings unveil a novel mechanism mediated by the mSWI/SNF complex in OE neurogenesis and development.