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Prof. Dr. Jochen Staiger

Prof. Dr. Bernhard Reuss

Gabriele Schmidt

Dr. rer. nat. Julien Guy

Dr. rer. nat. Martin Möck

Dr. med. Rebeka Andrea Palicz

Dr. Stefan Pommer

Dr. rer. nat. Joachim Rosenbusch

Dr. rer. nat. Mirko Witte

Merve Özgür Erat

Aybeniz Ece Cetin

Xiaoyi Mao

Felix Preuss

Jenifer Rachel

Harun Akkoyun

Felicita Fischer

Philipp Kolligs

Lukas Müller

Flore Schork

Sophia Heidenreich

Ima Mansori

Leander Matthes

Paul Molis

Sandra Heinzl

Sabrina Hübner

Patricia Sprysch

Pavel Truschow

Dr. rer. nat. Csaba Dávid

Dr. rer. nat. Alvar Prönneke

PD Dr. Michael Rickmann

Dr. Marcel Ruiz Mejias

Dr. rer. nat. Dirk Schubert

Dr. Godwin Sokpor

Dr. rer. nat. Nidhi Subhashini

Dr. rer. nat. Tran Tuoc

Dr. med. Robin Wagener

Dr. rer. nat. Yuanbin Xie

Dr. rer. nat. Xiaojuan Zhou

Eman Abbas

Weilin Chen

Michael Feyerabend

Georg Hafner

Kamila Kiszka

Anouk Meeuwissen

Nieves Mingo Moreno

Ramanathan Narayanan

Huong Nguyen

Pauline Antonie Ulmke

Florian Walker

Khatuna Aslanishvili

Christina Bachmann

Simon Badura

Thore Behrendt

Jürgen Delchmann

Esther Alexandra Dockhorn

Tatjana Fischer

Anna Garcia Galera

Kristina Glöckner

Janis Hülsemann

Dilbrin Khelo

Stephen Olt

Bettina Pater

Alina Rüppel

Alexandra Sachkova

Bianca Scheuer

Lisa Thiecke

Joris Brehmer

Dennis Dalügge

Julia Dziubek

Ricardo Castro Hernandez

Fernando Gonzalez Ibanez

Christin Korb

Anette Mertens

Megha Patwa

Adrián Villalobos

Simon Weiler

Maxim Wintergoller

Nicolas Zdun

Anna Dudek

Heike Faust

Sabrina Heide

Ansgar Jahn

Linh Pham


Smaller_eman
Eman

Abbas


Last Name: Abbas Position: PhD Student
First Name: Eman Location:
Academic Title: Tel.:

Publications

Curriculum Vitae


Publications

2021

H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion.
Cemil Kerimoglu, Linh Pham, Anton B. Tonchev, M. Sadman Sakib, Yuanbin Xie, Godwin Sokpor, Pauline Antonie Ulmke, Lalit Kaurani, Eman Abbas, Huong Nguyen, Joachim Rosenbusch, Alexandra Michurina, Vincenzo Capece, Meglena Angelova, Nenad Maricic, Beate Brand-Saberi, Miriam Esgleas, Mareike Albert, Radoslav Minkov, Emil Kovachev, Ulrike Teichmann, Rho H. Seong, Wieland B. Huttner, Huu Phuc Nguyen, Anastassia Stoykova, Jochen F. Staiger, Andre Fischer, Tran Tuoc.
Science Advances 2021; 7 : eabc6792, 2021.
abstract link

Increase in the size of human neocortex―acquired in evolution―accounts for the unique cognitive capacity ofhumans. This expansion reflects the evolutionarily enhanced proliferative ability of basal progenitors (BPs), includingthe basal radial glia and basal intermediate progenitors (bIPs) in mammalian cortex, which may have been acquiredthrough epigenetic alterations in BPs. However, how the epigenome in BPs differs across species is not known.Here, we report that histone H3 acetylation is a key epigenetic regulation in bIP amplification and cortical expansion.Through epigenetic profiling of sorted bIPs, we show that histone H3 lysine 9 acetylation (H3K9ac) is low inmurine bIPs and high in human bIPs. Elevated H3K9ac preferentially increases bIP proliferation, increasing the sizeand folding of the normally smooth mouse neocortex. H3K9ac drives bIP amplification by increasing expressionof the evolutionarily regulated gene, Trnp1, in developing cortex. Our findings demonstrate a previously unknownmechanism that controls cortical architecture.

Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain.
Eman Abbas, Mohamed A Hassan, Godwin Sokpor, Kamila Kiszka, Linh Pham, Cemil Kerimoglu, Andre Fischer, Huu Phuc Nguyen, Jochen F Staiger, Tran Tuoc.
Front Cell Dev Biol. 2021 Jul 15;9:619538., 2021.
link

2018

Transcriptional and epigenetic control of mammalian olfactory epithelium development.
Sokpor G*, Abbas E*, Rosenbusch J, Staiger JF, Tuoc T..
Molecular Neurobiology (https://doi.org/10.1007/s12035-018-0987-y), 2018.
abstract link

The postnatal mammalian olfactory epithelium (OE) represents a major aspect of the peripheral olfactory system. It is a pseudostratified tissue that originates from the olfactory placode and is composed of diverse cells, some of which are specialized receptor neurons capable of transducing odorant stimuli to afford the perception of smell (olfaction). The OE is known to offer a tractable miniature model for studying the systematic generation of neurons and glia that typify neural tissue development. During OE development, stem/progenitor cells that will become olfactory sensory neurons and/or non-neuronal cell types, display fine spatiotemporal expression of neuronal and non-neuronal genes that ensures their proper proliferation, differentiation, survival, and regeneration. Many factors, including transcription and epigenetic factors have been identified as key regulators of the expression of such requisite genes to permit normal OE morphogenesis. Typically, specific interactive regulatory networks established between transcription and epigenetic factors/cofactors orchestrate histogenesis in the embryonic and adult OE. Hence, investigation of these regulatory networks critical for OE development promises to disclose strategies that may be employed in manipulating the stepwise transition of olfactory precursor cells to become fully differentiated and functional neuronal and non-neuronal cell types. Such strategies potentially offer formidable means of replacing injured or degenerated neural cells as therapeutics for nervous system perturbations. This review recapitulates the developmental cellular diversity of the olfactory neuroepithelium and discusses findings on how the precise and cooperative molecular control by transcriptional and epigenetic machinery is indispensable for OE ontogeny.



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