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Prof. Dr. Jochen Staiger

Prof. Dr. Bernhard Reuss

Gabriele Schmidt

Dr. rer. nat. Julien Guy

Dr. rer. nat. Martin Möck

Dr. med. Rebeka Andrea Palicz

Dr. rer. nat. Joachim Rosenbusch

Dr. rer. nat. Mirko Witte

Merve Özgür Erat

Aybeniz Ece Cetin

Weilin Chen

Xiaoyi Mao

Anouk Meeuwissen

Felix Preuss

Jenifer Rachel

Pauline Antonie Ulmke

Harun Akkoyun

Simon Badura

Thore Behrendt

Felicita Fischer

Janis Hülsemann

Alina Rüppel

Lisa Thiecke

Sabrina Hübner

Christin Korb

Ima Mansori

Nicolas Zdun

Sandra Heinzl

Patricia Sprysch

Pavel Truschow

Dr. rer. nat. Csaba Dávid

Dr. rer. nat. Alvar Prönneke

PD Dr. Michael Rickmann

Dr. Marcel Ruiz Mejias

Dr. rer. nat. Dirk Schubert

Dr. Godwin Sokpor

Dr. rer. nat. Nidhi Subhashini

Dr. rer. nat. Tran Tuoc

Dr. med. Robin Wagener

Dr. rer. nat. Yuanbin Xie

Dr. rer. nat. Xiaojuan Zhou

Eman Abbas

Michael Feyerabend

Georg Hafner

Kamila Kiszka

Nieves Mingo Moreno

Ramanathan Narayanan

Huong Nguyen

Florian Walker

Khatuna Aslanishvili

Christina Bachmann

Jürgen Delchmann

Esther Alexandra Dockhorn

Tatjana Fischer

Anna Garcia Galera

Kristina Glöckner

Dilbrin Khelo

Stephen Olt

Bettina Pater

Alexandra Sachkova

Bianca Scheuer

Joris Brehmer

Dennis Dalügge

Julia Dziubek

Ricardo Castro Hernandez

Fernando Gonzalez Ibanez

Anette Mertens

Megha Patwa

Adrián Villalobos

Simon Weiler

Maxim Wintergoller

Anna Dudek

Heike Faust

Ansgar Jahn

Linh Pham


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Megha

Patwa


Last Name: Patwa Position: Master/Bachelor Student
First Name: Megha Location: Göttingen
Academic Title: Tel.:

Publications

Curriculum Vitae


Publications

2016

mSWI/SNF (BAF) complexes are indispensable for the neurogenesis and development of embryonic olfactory epithelium.
Bachmann C*, Nguyen H*, Rosenbusch J*, Pham L, Rabe T, Patwa M, Sokpor G, Seong RH, Ashery-Padan R, Mansouri A, Stoykova A, Staiger JF, Tuoc T..
Plos Genetics, 2016. 12(9), *equally contributed authors
abstract link

Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been reported to play essential roles in the neurogenesis of the central nervous system. However, whether BAF complexes are required for neuron generation in the olfactory system is unknown. Here, we identified onscBAF and ornBAF complexes, which are specifically present in olfactory neural stem cells (oNSCs) and olfactory receptor neurons (ORNs), respectively. We demonstrated that BAF155 subunit is highly expressed in both oNSCs and ORNs, whereas high expression of BAF170 subunit is observed only in ORNs. We report that conditional deletion of BAF155, a core subunit in both onscBAF and ornBAF complexes, causes impaired proliferation of oNSCs as well as defective maturation and axonogenesis of ORNs in the developing olfactory epithelium (OE), while the high expression of BAF170 is important for maturation of ORNs. Interestingly, in the absence of BAF complexes in BAF155/BAF170 double-conditional knockout mice (dcKO), OE is not specified. Mechanistically, BAF complex is required for normal activation of Pax6-dependent transcriptional activity in stem cells/progenitors of the OE. Our findings unveil a novel mechanism mediated by the mSWI/SNF complex in OE neurogenesis and development.



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